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Well, we've got a full spoiler to look over now and I've put in a pre-order for my must have singles.  Here is what's got me excited:

Genesis Wave :  Pre-ordered 2 of them at $1 each, which is a steal IMO.  Can't wait to fit it into my Azusa, and Elf decks.
Ezuri, Renegade Leader :  I was definitely happy to see this guy on the spoiler.  The first EDH deck I ever built was an Elf deck and this guy is going to fit perfectly.
Grasp of Darkness :  Great removal and it will probably replace Terror in my Drana deck.
Necrotic Ooze :  Here is a perfect example of a card that I will force into every deck I play for the next 6 months just because I think it should be awesome but it will only shine once out of every 10 plays.
Sunblast Angel :  I don't have a spot for this card yet but I think it will get play so I picked it up while it was still only $2.50.
Etched Champion :  Hot, super hot, damn hot.  I really like this guy.  Definitely going into my Sharuum deck and I probably should've picked up a playset for standard while they were still cheap.
Painful Quandary :  This is a hate card, plain and simple.  I play this card and I will lose the game because everyone will immediately gun for me.  I'll play it a couple times to stir things up but it's a foregone conclusion that it won't stay in my deck for more than a few games.
Steel Hellkite :  This will replace Filigree Angel in my Sharuum deck.
Prototype Portal :  I'll take another Soul Foundry , thanks!
Liege of the Tangle :  Azusa seems to be made for this guy.
Exsanguinate :  Wow, this is the best multiplayer card in the whole set and it is already proxied in my Drana deck.

A couple quick cards that caught my eye:

Leonin Arbiter :  Going to see some EDH play for sure.
Whitesun's Passage :  This is going to be the card that everyone under values for the first month of drafting.
Hand of the Praetors :  I think this will see lots of early play in standard, mainly because it's awesome.
Tainted Strike :  To me this seems like a really really powerful card and I think it's going piss some players off.
Koth of the Hammer :  Jeebus this guy is incredibly overpriced.  Look for this to fall to around $30 in the coming months.
Hoard-Smelter Dragon :  It's a given that this will see heavy EDH play.  I think it will see some maindeck play as well and definitely will fill a lot of sideboards in standard.
Spikeshot Elder :  Definitely a bulk rare but I like it.
Asceticism :  On paper this seems awesome but I doubt I'll ever actually play it in anything.
Glint Hawk Idol :  I think this will be a solid pick 4-5 in draft but we'll see.
Kuldotha Forgemaster :  This thing was built for the Johnny EDH player.
Lux Cannon :  I really wanted to pick up a couple of these but they are overpriced right now by default for being a mythic. 
Mox Opal :  I can't believe people are valuing this at more than $30.  You can't have more than 1 on the board at once and it hinges on the number of artifacts you have in play.  This is maybe a $20 card IMO.
Nim Deathmantle :  This is probably the best equipment in the set; besides Sword of Body and Mind of course.
Infiltration Lens :  Probably the second best equipment in the set.

At a glance I'd say that blue is going to be the weakest color in the set, infect make black and green the strongest, drafting a straight infect deck is probably going to be tough because creatures dealing damage in -1/-1 counters makes them great in any deck, and myr will probably get picked pretty high (as they should).  I think I might proxy up a standard myr deck.  It seems like you'd be able to play all the best cards from multiple colors pretty easily in a myr deck and still have a decent amount of early aggression.

Good luck to anyone playing in pre-releases this weekend!