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Something like Vader (SM|lock/assassin/sigil carver) works pretty well and has pretty insane defences - teleport everyround for +2 AC/Reflex, make that teleport at least 3 squares (ethereal sidestep and a +2 incisive dagger) for constant concealment, and wear armour of dark majesty for +2 to all defences against curses enemies. So effectively you are at +6/+4/+6/+4 over your basic defences pretty much all the time.