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whats a good spell to exile with   isochron scepter ?

depends what deck your running

red: the all time favorite lightning bolt , ive also seen reverberate
blue: counterspell ,   redirect , stuff that makes you draw
black: doom blade
white: i agree with silence , angel's grace
green: stuff like titanic growth is nice

good combos i've also seen are dramatic rescue , also all of the new charms for their flexibility and usefullness

fire // ice

snap  

Counterspell , Silence , and Tangle are all traditionally good targets.

Other options:

Heroes' Reunion or Lightning Helix can be crushing if you already have Drogskol Reaver out somehow .
In fact, any cantrip is good. I like giving my golems an Aggressive Urge or some Tel-Jilad Defiance .
Druid's Deliverance works for the same reason Tangle does.
In red, Galvanic Blast . Just two more artifacts and you get to wipe your opponent out, one hit at a time.
In black, Doom Blade or Go for the Throat or Eyeblight's Ending is a good way to get rid of creatures.
In white, Break of Day is great, especially when you're at low life.

By the way, the stick loves cantrips. I love Aggressive Urge or Tel-Jilad Defiance on a Precursor Golem for a repeatable Ancestral Recall for .

Split card hilarity:

You can use either half of the split card. Remember this.

Bound // Determined can get you lots of cards. Remember, you're casting a copy, so you exile the copy after it resolves. Then it doesn't exist anymore. Or stop counters.
Dead // Gone gives you a Shock or...an Unsummon that only works on creatures you don't control. ( Splinter your opponent's Torpor Orb , cast it on his Phyrexian Dreadnought , and watch him cry.)
Stand // Deliver is fun. "Don't worry, I'm not playing land destruction." It's also a bounce spell you can use on your own stuff. Or it can prevent infect/deathtouch/wither damage better than a +0/+X spell could.
Research // Development lets your opponent decide: Ancestral Recall , three 3/1s, or somewhere in between.
Odds // Ends can trigger a surrender a deck that doesn't have a lot of tokens or recursion. (Or a Tajuru Preserver or Bubbles ). Odds is a fun little coin flip card that does "heads I win, tails you lose".
Trial // Error is cool with Lure . The Trial half is anyway. Error's kinda narrow.
Fire // Ice Cantrip!
Hide // Seek can mess up combo decks a lot.
Wax // Wane is strictly better than Demystify , in that it can get you +2/+2.