I got a chance to play Lords of Waterdeep at DDXP this past weekend (3 player game). Wow, it's awesome. I can't wait to get a copy for myself.
Gameplay: I don't like Euro games or resource management games but loved this. It really has something for everyone in it.
I was overwhelmed with the rules in game setup and expected to dislike it but after just 1 round of play it became second nature.
I was absolutely crushed by the other 2 players. I played awfully and still had a blast just doing my own thing.
Feel: It is FILLED with FR lore. I spent time reading a lot of the flavor text when I wasn't planning my next move.
Packaging: Top notch. Everything has it's own home so no more plastic baggies for me.
Price: As others have said $50 is a little high for wooden blocks (No minis in this). There is a lot of game pieces though and the excellent interior packaging is a bonus. I won't bat an eye about the price because I think the game is a good value for what I will get out of it.
Bonus: You can play with 2 players. I know the wife and I will be getting a lot of fun out of this game.