"Be careful to choose your enemies well. Friends don't much matter. But the choice of enemies is very important."
- Oscar Wilde
The entry on Waterdeep drops several names of important figures. It is for you to flesh them out based on what the needs of your campaign are. Of course there are several Waterdeep products from earlier editions which can be used for names, noble houses, and generally background history. I expect there will be future DDI articles.
Read Steven Schend's Blackstaff Tower novel -- part of the "Ed Greenwood Presents Waterdeep" series. It features a few brief updates on some of the high-ups and major personages in the political/societal landscape of the post-Spellplague City of Splendors.
HAND OF KARSUS!
IIRC the "Ed Greenwood Presents: Waterdeep" series will be around 40 books strong.