Creating NPCs with Char Builder

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Hello all,
New DM here, and am getting my head around the new rules for monster and NPC creation.

Is there any reason I should not use the Character Builder to make PCs? I notice in the DMG that we should just choose one each of at will, encounter, daily and utility powers; that is no problem to do in the CB. Is there any other reason?

My first impression is that the stats and bonuses will be higher if built in the CB, but I'm not sure...